Google Adsense provides the answer to this. In their help files they provide details on where on the screen gets the highest click through, the best colours to use, which ad formats work best. They also have details on optimizing forums and blogs too.
If you really want to succeed with Google Adsense you should probably consider redesigning your site to fix the best performing Adsense blocks, rather than selecting the adsense blocks to fit the available space on your site.
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